CSS3/JavaScript for styling: Your opinion matters

I’m planning to switch to a new style which relies heavily on CSS3 and JavaScript. This means for instance that certain parts might absolutely require JavaScript and not work correctly with JavaScript disabled (for instance, tabs might load their content using AJAX without a fallback.) However, before I spend time working on this new style I’d like to get some opinions from you, my dear readers …

• Do you mind requiring JavaScript?
• Do you prefer JavaScript linked off a CDN or hosted locally? (For instance, I could pull JQuery from Microsoft’s CDN)
• Do you plan to keep your browser up-to-date to follow new web-standards or do you update rather casually?

Please comment or drop me a line using the contact form, so I can flesh out a nice and useful redesign plan.